Buprenorphine and Metabolites, Serum or Plasma, Quantitative
Ordering Recommendation
Use to monitor patient adherence.
New York DOH Approval Status
Specimen Required
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP standard transport tube. (Min: 1 mL)
Refrigerated.
Separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Specimens exposed to repeated freeze/thaw cycles. Hemolyzed specimens.
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Fri
Reported
1-7 days
Reference Interval
Effective February 16, 2016
Drugs Covered | Cutoff Concentrations |
---|---|
Buprenorphine | 1 ng/mL |
Norbuprenorphine | 1 ng/mL |
Interpretive Data
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive cutoff: 1 ng/mL
For medical purposes only; not valid for forensic use.
The presence of metabolite(s) without parent drug may indicate use of parent drug during the prior week. The absence of expected drug(s) and/or drug metabolite(s) may indicate noncompliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
80348 (Alt code: G0480)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2002743 | Norbuprenorphine, S/P, Quant | 53881-9 |
2002745 | Buprenorphine, S/P, Quant | 3413-2 |
Aliases
- Belbuca
- Buprenex
- Buprenorphine and Metabolite, Serum (Buprenorphine & Metabolites - Confirmation/Quantitation - Serum
- Butrans
- Narcan
- Norbuprenorphine Glucuronide (Buprenorphine & Metabolites - Confirmation/Quantitation - Serum/Plasma
- Probuphine
- Sublocade
- Suboxone
- Subutex
- Temgesic
- Transtec
- Vetergesic
- Zubsolv